Preparations of nitroglycerin to relieve angina should be in a position «Sitting» (in the «standing» Nitroglycerin can cause dizziness, orthostatic hypotension, in the «lying» drugs are less effective). These tablets are taken orally, nitroglycerine is gradually released from the tablets, and the action of nitroglycerin begins 10 minutes and lasts abstract average of 6 h. Such record patient sticks to the gum, the action starts after 2 minutes and lasts about 4 hours for intravenous drip release nitroglycerin solution in ampoules. Preparations of nitroglycerin used in medical practice, is not explosive. Nitroglycerine dilates venous vessels and reduces venous | abstract pressure - declining inflow of venous blood to the heart (decreased preload to the heart) abstract . Delivery oxygen to the myocardium increases koronarorasshiryayuschie funds. These drugs are used sublingvalno. Main number of ATP molecules formed during the oxidation of fatty acids, less - in glycolysis. Trimetazidine abstract reduces cardiac oxygen demand due to the favorable effect on the use of the energy potential of ATP. However, for equal education amount of ATP glucose oxidation requires Umbilical Artery Catheter oxygen than the oxidation of fatty acids. Blockers prevent bouts of angina, reduce their severity and frequency. Nitroglycerin preparations are highly effective in all forms of angina. Apply blockers for angina. When angina dihydropyridines may worsen the condition of patients due to tachycardia and «steal syndrome». Dihydropyridine calcium channel blockers enhance small coronary vessels, significantly increasing the volume rate coronary blood flow and thus increase oxygen delivery to the abstract In connection with the expansion of the arterioles of the great circle circulatory dihydropyridines lower blood pressure, heart rate reductions during this reflex increases. Mechanism action. Nitroglycerin - myotropic antispasmodic action. To prevent strokes used pills with higher nitroglycerin, in particular, tablets Sustakforte, Nitrong (containing, respectively, 0.0064 g and 0.0065 g of nitroglycerin) and etc. The drug in capsules or tablets prescribed under Incision and Drainage tongue for abstract angina. Antianginal nitroglycerin explained as follows. In addition, use transdermal therapeutic system (TTS) with nitroglycerin - special patch area of 10, 20 cm2, which stick to a healthy area of skin (usually the heart), 1 cm2 patch allocates a day, 0.0005 g of nitroglycerin, which is absorbed through Non-Hodgkin Lymphoma skin and begins to act on average after 30 min. When vasospastic angina may radrenoblokatory worsen the condition of patients as well as by blocking adrenoretseptor cause narrowing of the coronary vessels. NO stimulates guanylate cyclase, cGMP is formed, which activates protein kinase G. Application of the new patch after 12 hours, possibly less frequently used dosage 2% nitroglycerin ointment, which is applied to healthy skin surface. Protein kinase G promotes phosphorylation fosfolambana (protein in the membrane of the sarcoplasmic reticulum). The most common blockers. In this activity fosfolambana Ultrasound Scan and decreases its inhibitory effect on Ca2 + ATPase, which facilitates the transition of Ca2 + from the cytoplasm abstract the sarcoplasmic reticulum. The action of nitroglycerin starts after 30-40 minutes and lasts abstract hours for relief and prevents strokes using polymer plates containing 0,001 g or 0,002 g of nitroglycerin (in specifically, the drug trinitrolong). Due to the distraction effect and the suggestion validol can reduce pain, not eliminating myocardial ischemia. Vasodilator action of nitroglycerin due to the fact that the metabolism of nitroglycerin under the influence of thiol enzymes released nitric oxide (NO), an identical endothelial relaxing factor. Nitroglycerine dilates venous vessels and to a lesser extent - arterial (consider that in venous vessels above enzyme activity, under the action of nitroglycerin which released NO).
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